The beloved nurses and nuns of Nonnatus House return to warm your heart as they care for the poorest women in London's East End. Life never stands still as the midwives face surprise pregnancy, disease, blossoming romance and missing friends.

It's 1966, and it's a testing time for the midwives. But there's excitement, too, as the women's rights movement intensifies. With Trixie's help, Sister Julienne is determined to steer Nonnatus House of its financial quandary. Dr. Turner deals with an array of difficult cases including a former soldier involved in nuclear test explosion. Meanwhile, Sister Monica Joan experiences a crisis of faith, and Sister Frances realizes she needs to be a little less spiritual if she's to really connect with the local women. There are some interesting challenges ahead, as well as great celebrations when England wins the World Cup.

It's 1968 and Enoch Powell's infamous "Rivers of Blood" speech creates serious tension in Poplar, especially when a group of dockers march in support of Powell. The midwives welcome a new nun, Sister Veronica, who's an instant hit with everyone, except Nurse Crane. Meanwhile, Trixie's relationship with Matthew goes from strength to strength, while Nurse Crane helps Nancy with her financial woes. Sister Julienne enjoys helping out on the district rounds, Shelagh and Dr. Turner split their time between the busy maternity home and their lively young family, while Reggie continues to bring joy into Violet and Fred's lives.

1967 brings fresh medical and personal challenges to the midwifery and district nursing rounds. Thanks to Matthew's continued support, things at Nonnatus House are now settled and going well, and Trixie helps Matthew understand the community he is becoming a part of. Doctor Turner faces some changes in his relationship with Timothy now that he is an adult, while Shelagh continues to support community health programs. Across the series, the team faces challenging situations concerning addiction, a baby with a life-threatening condition, breastfeeding difficulties, and a Holocaust survivor.

When the rather austere Sister Ursula is appointed the new head of Nonnatus house, Sister Julienne finds herself demoted and working back alongside the midwives as an ordinary member of staff.

Now nearing the 1960s, the community enters a new time of social change, while stories of birth, life and death continue to touch your heart. Will live-wire Nurse Trixie marry her young curate? What new project calls for a heart as big as Chummy's? How will Sister Evangelina react to two new nurses? And why does Sister Julienne appear so unsettled by a mystery benefactor?

In 1957, twenty-two year old Jenny leaves her home to become a midwife in a deprived nursing convent helping poor pregnant mothers coping with harsh living conditions.

In 1957, twenty-two year old Jenny leaves her home to become a midwife in a deprived nursing convent helping poor pregnant mothers coping with harsh living conditions.