After his brother's suicide, Leopold Bloom King struggles along with the rest of his family in Charleston, South Carolina, until he begins to gather an intimate circle of friends, whose ties endure for two decades until a final, unexpected test of friendship.

Leopold Bloom King, the narrator, is the son of an amiable, loving father who teaches science at the local high school. His mother, an ex-nun, is the high school principal and a well-known Joyce scholar. After Leo's older brother commits suicide at the age of thirteen, the family struggles with the shattering effects of his death. Eventually he becomes part of a tightly knit group of high school seniors that includes friends Sheba and Trevor Poe, glamorous twins with an alcoholic mother and a prison-escapee father; hardscrabble mountain runaways Niles and Starla Whitehead; socialite Molly Huger and her boyfriend, Chadworth Rutledge X; and an ever-widening circle whose liaisons will ripple across two decades-from 1960s counterculture through the dawn of the AIDS crisis in the 1980s.