In 1916, Georgia O'Keeffe is a young, unknown art teacher when she travels to New York to meet Stieglitz, the famed photographer and art dealer, who has discovered O'Keeffe's work and exhibits it in his gallery. Their connection is instantaneous. O'Keeffe is quickly drawn into Stieglitz's sophisticated world, becoming his mistress, protégé, and muse, as their attraction deepens into an intense and tempestuous relationship and his photographs of her, both clothed and nude, create a sensation. Yet as her own creative force develops, Georgia begins to push back against what critics and others are saying about her and her art. And soon she must make difficult choices to live a life she believes in.