Pakistan-born comedian Kumail Nanjiani and grad student Emily Gardner fall in love but struggle as their cultures clash. When Emily contracts a mysterious illness, Kumail finds himself forced to face her feisty parents, his family's expectations, and his true feelings.

Pakistan-born aspiring comedian Kumail connects with grad student Emily after a standup set. However, what they thought would be just a one-night stand blossoms into the real thing.