Seven Key Terms and Conventions ix
Prologue: A Good War Gone Bad
Ricky's Story
3(4)
Daniel's Story
7(2)
Revenge of the Microbes?
9(6)
PART I: THE WAR ON GERMS
From Miasmas to Microbes
15(5)
Germ Theory Reborn
20(6)
The Sanitarians
26(3)
The Search for Magic Bullets
29(6)
PART II: LIFE ON MAN
The Body as Ecosystem
35(2)
Into the Mouths of Babes
37(4)
Life on the Surface
41(3)
Life on the Inside
44(1)
Bugs in Space
45(4)
Where No Biologist Has Gone Before
49(3)
The Inner Tube of Life
52(7)
Who's the Boss?
59(5)
A New Window Opens
64(3)
Stealth Infections or Innocent Bystanders?
67(6)
PART III: TOO CLEAN?
Hair Trigger
73(3)
From Hippocrates to the Hygiene Hypothesis
76(5)
A History of Self-Destruction
81(2)
Children in the Cowshed
83(4)
Teaching Tolerance
87(2)
Innate Immunity
89(2)
The Dirt Vaccine
91(6)
Old Friends
97(4)
Beyond Immunity
101(4)
PART IV: BUGS ON DRUGS
A Killer in the Nursery
105(4)
An End to Bacterial Disease?
109(2)
Microscopic Mating Games
111(4)
The Bacterial Superorganism
115(1)
Danger Ignored
116(4)
Old Habits, New Insights
120(5)
Out of the Hospital and into Our Daily Lives
125(6)
The Reservoir Within
131(5)
Resistance by the Shovel
136(5)
Down on the Farm
141(7)
The Antibiotic Paradox
148(3)
PART V: FIGHTING SMARTER, NOT HARDER
The Good Old Days?
151(3)
Preserving Antibiotics: Less Is More
154(4)
Homing In on the Enemy
158(5)
Drugs with On-Off Switches
163(2)
Silencing Resistance
165(3)
Farming Out Resistance
168(2)
Beyond Antibiotics: New Ways to Kill
170(6)
Cocoons and Frog Slime
176(9)
PART VI: BEYOND LETHAL FORCE - DEFANG, DEFLECT, AND DEPLOY
Drugs That Disarm
185(4)
Vaccines---Forewarned is Forearmed
189(4)
Domesticate and Deploy
193(3)
Prescription Probiotics
196(3)
Fighting Fire with Fire
199(4)
A Superhero for the Mouth
203(2)
Transgenic Probiotic
205(7)
Probiotics for Livestock
212(2)
A Second Neolithic Revolution
214(5)
PART VII: FIXING THE PATIENT
The Dragon Within
219(6)
Enhancing the Bionic Human
225(3)
From Sepsis to Chronic Inflammation
228(4)
Immunobug Immunodrugs
232(1)
Tweaking the Bug
233(1)
Into the Future
234(1)
Coda: Embracing The Microbiome 235(4)
Notes 239(34)
Further Reading 273(2)
Acknowledgments 275(2)
Index 277